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KMID : 1123920080220030607
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 3 p.607 ~ p.611
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Effect of Houttuynia cordata Thunb and Herbs Mixture Extract on the Lipid Metabolism in the LPS-induced Hepatotoxicity
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Kwon Ryun-Hee
Na Baeg-Ju
Park Si-Jun
Mun Yeun-Ja
Woo Won-Hong
Lee Moo-Sik
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Abstract
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Lipopolysaccharide (LPS) induces the synthesis of several inflammatory cytokine, chemokine, NO and inflammation in the liver of rats. The purpose of this study was to investigate the preventive effects of Houttuynia cordata Thunb and Oriental herbs mixture extract (HCTM) against the hepatotoxicity-inducing LPS in the lipid metabolism. HCTM of 100 mg/kg concentration was intra-peritoneally administered into rats at dose of 1.5 ml/kg for 20 days. On the day 21, 1.5 ml/kg of LPS was injected 4 hours before anesthetization. The levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), total lipid, triglyceride (TG) and HDL-cholesterol (HDL-C) were measured in serum. LPS-treatment markedly increased the levels of GOT, GPT, total lipid and TG, and decreased the level of HDL-C. However, HCTM pretreatment decreased the levels of GOT, GPT, total lipid and TG by 76.8%, 55.48%, 34.04% and 76.21% respectively, and increased the level of HDL-C by 97.84%. These results showed that HCTM had the protective effect against the hepatotoxicity-inducing LPS in the lipid metabolism, and it suggest that HCTM could be used for functional beverage.
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KEYWORD
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Houttuynia cordata, GOT, GPT, total lipid, triglyceride, HDL-cholestrol
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